Peer-reviewed Articles

In this section, you may find the titles of some of the latest published research and review articles of our group, as well as their respective links. Papers conserning the delicate issue of "Nanosimilarity" are also listed. A full list of past publications is provided in this link.

 2024

• Nanosimilars: A Scientific or A Regulatory Debate? Demetzos C., The AAPS Journal
• Development and in vitro evaluation of liposomal carnosine for dermatological and cosmeceutical applications., Katsogiannis I., et al., Journal of Drug Delivery Science and Technology
• Lipidic Nanoparticles, Extracellular Vesicles and Hybrid Platforms as Advanced Medicinal Products: Future Therapeutic Prospects for Neurodegenerative Diseases, Tsakiri M., et al., Pharmaceutics
• Exosome-like genistein-loaded nanoparticles developed by thin-film hydration and 3D-printed Tesla microfluidic chip: A comparative study, Tsakiri M., et al., International Journal of Pharmaceutics

 2023

• Development of Liposomal and Liquid Crystalline Lipidic Nanoparticles with Non-Ionic Surfactants for Quercetin Incorporation, Tsichlis I., et al., Materials
•  A mini review for lipid-based nanovaccines: from their design to their applications, Xekouki K., et al., Journal of Liposomes Research
•  Interaction of Rhus typhina Tannin with Lipid Nanoparticles: Implication for the Formulation of a Tannin–Liposome Hybrid Biomaterial with Antibacterial Activity, Sekowski S., et al., Journal of Functional Biomaterials
  
• Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites, Stampolaki M., et al., ACS Infectious Diseases
• Development of stimuli-responsive lyotropic liquid crystalline nanoparticles targeting lysosomes: Physicochemical, morphological and drug release studies, Chountoulesi M., et al., International Journal of Pharmaceutics
• Protein-liposome interactions: The impact of surface charge and fluidisation effect on protein binding, Triantafyllopoulou E., et al., Journal of Liposome Research
• Preclinical evaluation of modified carbon nanohorns and their complexation with insulin. Stangel C., et al., Nanoscale Advances
• Concomitant delivery of doxorubicin and cisplatin through liposome-based thermosensitive nanoparticles: Perspective in the treatment of cancer in animal models. Maswadeh HM,  et al. American Journal of Cancer Research

2022

• Lipid-based nanoparticles and RNA as innovative neuro-therapeutics., Tsakiri M., et al., Frontiers in Pharmacology
• Development and evaluation of liposomal nanoparticles incorporating dimethoxycurcumin. In vitro toxicity and permeability studies. Zouliati K, et al. Colloids and Surfaces A: Physicochemical and Engineering Aspects.
• Development and physicochemical characterization of nanoliposomes with incorporated oleocanthal, oleacein, oleuropein and hydroxytyrosol. Wenjun L, et al. Food Chemistry.
• Losartan Interactions with 2-Hydroxypropyl-β-CD. Palli V, et al. Molecules.
• Hydrophilic Random Cationic Copolymers as Polyplex-Formation Vectors for DNA. Chrysostomou V, et al. Materials.
• Lyotropic Liquid Crystalline Nanostructures as Drug Delivery Systems and Vaccine Platforms. Chountoulesi M, et al. Pharmaceuticals.
• Structure of micelleplexes formed between QPDMAEMA-b-PLMA amphiphilic cationic copolymer micelles and DNA of different lengths. Chrysostomou V, et al. European Polymer Journal.
• The technology of transdermal delivery nanosystems: from design and development to preclinical studies. Despotopoulou D, et al. International Journal of Pharmaceutics.
• Design and development of DSPC:DAP:PDMAEMA-b-PLMA nanostructures: from the adumbration of their morphological characteristics to in vitro evaluation. Pippa N, et al. Colloids and Surfaces A: Physicochemical and Engineering Aspects.
• Chimeric liposomes decorated with P407: an alternative biomaterial for producing stealth nano-therapeutics. Tsakiri M, et al. Journal of Liposome Research.

2021

• Innovative vaccine platforms against infectious diseases: under the scope of the COVID-19 pandemic. Tsakiri M, Naziris N, Demetzos C. International Journal of Pharmaceutics.
• Chaotic Dynamics and Stability of Liposomal Nanosystems. Naziris N, Chountoules M, Stavrinides S, Hanias M, Demetzos C. Current Nanoscience.
• Thermoresponsive chimeric nanocarriers as drug delivery systems. Naziris N, Pippa N, Skandalis A, Miłowska K ,Balcerzak L ,Pispas S, Bryszewska M, Demetzos C. Colloids and Surfaces B: Biointerfaces.
• The influence of hydrophobic blocks of PEO-containing copolymers on glyceryl monooleate lyotropic liquid crystalline nanoparticles for drug delivery. Forys A, Chountoulesi M, Mendrek B, Konieczny T, Sentoukas T, Godzierz M, Kordyka A, Demetzos C, Pispas S, Trzebicka B. Polymers.
• Chimeric stimuli-responsive liposomes as nanocarriers for the delivery of the anti-glioma agent TRAM-34. Naziris N, Pippa N, Sereti E, Chrysostomou V, Kędzierska M, Kajdanek J, Ionov M, Miłowska K, Balcerzak Ł, Garofalo S, Limatola C, Pispas S, Dimas K, Bryszewska M, Demetzos C. International Journal of Molecular Sciences.
• Chimeric liposomes incorporating functional copolymers: preparation and pH/thermo-responsive behaviour in aqueous solutions. Sentoukas T, Demetzos C, Pispas S. Journal of Liposome Research.
• Formation of uni-lamellar vesicles in mixtures of dppc with peo-b-pcl amphiphilic diblock copolymers. Papagiannopoulos A, Pippa N, Demetzos C, Pispas S, Radulescu A. Polymers.
• Lamellarity and size distributions in mixed DPPC/amphiphilic poly(2-oxazoline) gradient copolymer vesicles and their temperature response. Papagiannopoulos A, Pippa N, Demetzos C, Pispas S, Radulescu A. Chemistry and Physics of Lipids.
• Liquid crystalline nanoparticles for drug delivery: The role of gradient and block copolymers on the morphology, internal organisation and release profile. Chountoulesi M, Perinelli DR, Forys A, Bonacucina G, Trzebicka B, Pispas S, Demetzos C. European Journal of Pharmaceutics and Biopharmaceutics.

2020

• Preparation and Biophysical Characterization of Quercetin Inclusion Complexes with β-Cyclodextrin Derivatives to be Formulated as Possible Nose-to-Brain Quercetin Delivery Systems. Manta K, Papakyriakopoulou P, Chountoulesi M, Diamantis DA, Spaneas D, Vakali V, Naziris N, Chatziathanasiadou MV, Andreadelis I, Moschovou K, Athanasiadou I, Dallas P, Rekkas DM, Demetzos C, Colombo G, Banella S, Javornik U, Plavec J, Mavromoustakos T, Tzakos AG, Valsami G. Molecular Pharmaceutics.
• A novel, nontoxic and scalable process to produce lipidic vehicles. Naziris N, Pippa N, Demetzos C. Materials.
• Coating of magnetic nanoparticles affects their interactions with model cell membranes. Lazaratos M, Karathanou K, Mainas E, Chatzigoulas A, Pippa N, Demetzos C, Cournia Z. Biochimica et Biophysica Acta - General Subjects.
• Promising nanotechnology approaches in treatment of autoimmune diseases of central nervous system. Chountoulesi M, Demetzos C. Brain Sciences.
• Incorporation of PEGylated δ-decalactone into lipid bilayers: thermodynamic study and chimeric liposomes development. Pippa N, Skouras A, Naziris N, Biondo F, Tiboni M, Katifelis H, Gazouli M, Demetzos C, Casettari L. Journal of Liposome Research.
• A thermal analysis and physicochemical study on thermoresponsive chimeric liposomal nanosystems. Naziris N, Skandalis A, Forys A, Trzebicka B, Pispas S, Demetzos C. Journal of Thermal Analysis and Calorimetry.
• Antihypertensive activity and molecular interactions of irbesartan in complex with 2-hydroxypropyl-β-cyclodextrin. Leonis G, Christodoulou E, Ntountaniotis D, Chatziathanasiadou MV, Mavromoustakos T, Naziris N, Chountoulesi M, Demetzos C, Valsami G, Damalas DE, Tzakos AG, Thomaidis NS, Karageorgos V, Liapakis G. Chemical Biology and Drug Design.
• Physicochemical, morphological and thermal evaluation of lyotropic lipidic liquid crystalline nanoparticles: The effect of stimuli-responsive polymeric stabilizer. Chountoulesi M, Perinelli DR, Pippa N, Chrysostomou V, Forys A, Otulakowski L, Bonacucina G, Trzebicka B, Pispas S, Demetzos C. Colloids and Surfaces A: Physicochemical and Engineering Aspects.
• The boundary lipid around DMPC-spanning influenza A M2 transmembrane domain channels: Its structure and potential for drug accommodation. Konstantinidi A, Chountoulesi M, Naziris N, Sartori B, Amentisch H, Mali G, Čendak T, Plakantonaki M, Triantafyllakou I, Tselios T, Demetzos C, Busath DD, Mavromoustakos T, Kolocouris A. Biochimica et Biophysica Acta (BBA) - Biomembranes.
• Nanomedicines and Nanosimilars: Looking for a New and Dynamic Regulatory “Astrolabe” Inspired System. Demetzos C, Kavatzikidou P, Pippa N, Stratakis E. AAPS PharmSciTech.
• pH-responsive chimeric liposomes: From nanotechnology to biological assessment. Naziris N, Saitta F, Chrysostomou V, Libera M, Trzebicka B, Fessas D, Pispas S, Demetzos C . International Journal of Pharmaceutics.

2019

• Physicochemical study of the protein–liposome interactions: influence of liposome composition and concentration on protein binding. Foteini P, Pippa N, Naziris N, Demetzos C. Journal of Liposome Research.
• Preparation and physicochemical characterization of elastic liposomes: a road-map library for their design. Chatzinikoli L, Pippa N, Demetzos C. Journal of Liposome Research.
• Carbon nanohorn/liposome systems: Preformulation, design and in vitro toxicity studies. Pippa N, Stangel C, Kastanas I, Triantafyllopoulou E, Naziris N, Stellas D, Zhang M, Yudasaka M, Demetzos C, Tagmatarchis N. Materials Science and Engineering: C.
• Stimuli-Responsive Lyotropic Liquid Crystalline Nanosystems with Incorporated Poly(2-Dimethylamino Ethyl Methacrylate)-b-Poly(Lauryl Methacrylate) Amphiphilic Block Copolymer. Chountoulesi M, Pippa N, Chrysostomou V, Pispas S, Chrysina ED, Forys A, Otulakowski L, Trzebicka B, Demetzos C. Polymers.
• PEO-b-PCL grafted niosomes: The cooperativilty of amphiphilic components and their properties in vitro and in vivo. Pippa N, Naziris N, Stellas D, Massala C, Zouliati K, Pispas S, Demetzos C, Forys A, Marcinkowski A, Trzebicka B.  Colloids and Surfaces B: Biointerfaces.

2018

• Development and Evaluation of Stimuli-Responsive Chimeric Nanostructures. Naziris N, Pippa N, Stellas D, Chrysostomou V, Pispas S, Demetzos C, Libera M, Trzebicka B. AAPS PharmSciTech.
• Cubic lyotropic liquid crystals as drug delivery carriers: Physicochemical and morphological studies. Chountoulesi M, Pippa N, Pispas S, Chrysina ED, Forys A, Trzebicka B, Demetzos C. International Journal of Pharmaceutics.
• Comparative Perturbation Effects Exerted by the Influenza A M2 WT Protein Inhibitors Amantadine and the Spiro[pyrrolidine-2,2'-adamantane] Variant AK13 to Membrane Bilayers Studied Using Biophysical Experiments and Molecular Dynamics Simulations. Konstantinidi A, Naziris N, Chountoulesi M, Kiriakidi S, Sartori B, Kolokouris D, Amentisch H, Mali G, Ntountaniotis D, Demetzos C, Mavromoustakos T, Kolocouris A. Journal of Physical Chemistry B.
• Physicochemical study of the protein-liposome interactions: influence of liposome composition and concentration on protein binding. Foteini P, Pippa N, Naziris N, Demetzos C.  Journal of Liposome Research.
• Marine sulfated polysaccharides as versatile polyelectrolytes for the development of drug delivery nanoplatforms: Complexation of ulvan with lysozyme. Tziveleka LA, Pippa N, Georgantea P, Ioannou E, Demetzos C, Roussis V. International Journal of Biological Macromolecules.

2017

• The Formation of Chimeric Nanomorphologies, as a Reflection of Naturally Occurring Thermodynamic Processes. N. Naziris, C. Demetzos. Journal of Physics: Conference Series.
• Magnetic nanoparticles coated with polyarabic acid demonstrate enhanced drug delivery and imaging properties for cancer theranostic applications. M. Patitsa, K. Karathanou, Z. Kanaki, L. Tzioga, N. Pippa, C. Demetzos, D.A. Verganelakis, Z. Cournia, A. Klinakis. Scientific Reports.
• Morphological diversity of block copolymer/lipid chimeric nanostructures. N. Naziris, N. Pippa, V. Chrysostomou, S. Pispas, C. Demetzos, M. Libera, B.Trzebicka. Journal of Nanoparticle Research.
• Design and development of multi-walled carbon nanotube-liposome drug delivery platform. N.Pippa, D.D. Chronopoulosm D. Stellas, R. Fernandez-Pachero, R. Arenal, C. Demetzos, N. Tagmatarchis. International Journal of Pharmaceutics.

2016

• Chimeric lipid/block copolymer nanovesicles: physicochemical and bio-compatibility evaluation. N. Pippa, D. Stellas, A. Skandalis, S. Pispas, C. Demetzos, M. Libera, A. Marcinkowski, B. Trzebicka. European Journal of Pharmaceutics and Biopharmaceutics.
• Stimuli-responsive survey of Hellenic Pharmaceutical Society to detect learning attitudes and needs of Greek pharmacists towards Continuing Professional Development (CPD). C. Demetzos, A.Tsantili, E. Skaltsa, A. Siamidi, G. Koutepas, N. Pippa, K. Gardikis, I. Chinou, O. Tzakou, S. Hantziantoniou, K. Ghirtis. European Journal of Pharmaceutical Sciences.
• Stimuli-responsive drug delivery nanosystems: from bench to clinic. N. Naziris, N. Pippa, S. Pispas, C. Demetzos. Current Nanomedicine.
• Design and development of pH-responsive HSPC:C12H25-PAA chimeric liposomes. N. Naziris, N. Pippa, A. Meristoudi, S. Pispas, C. Demetzos. Journal of Liposome Research.
• Polymer self-assembled nanostructures as innovative drug nanocarrier platforms. N. Pippa, S. Pispas, C. Demetzos. Current Pharmaceutical Design.

2015

• Delivery nanoparticle platform of liposomes – incorporated dendrimers: physicochemical, and thermotropic characterization. N. Pippa, S. Pispas, C. Demetzos. Advanced Science, Engineering and Medicine.
• Complexation of cationic-neutral block polyelectrolyte with insulin and in vitro release studies. N. Pippa, M. Karayianni, S. Pispas, C. Demetzos. International Journal of Pharmaceutics.
• Insulin/Poly(ethylene glycol)-block-poly(L-lysine) Complexes: Physicochemical Properties and Protein Encapsulation. N. Pippa, R. Kalinova, I. Dimitrov, S.Pispas, C.Demetzos. Journal of Physical Chemistry B.
• Temperature-dependent drug release from DPPC:C12H25-PNIPAM-COOH liposomes: control of the drug loading/release by modulation of the nanocarriers' components. N. Pippa, A. Meristoudi, S. Pispas, C. Demetzos. International Journal of Pharmaceutics.

Papers on Nanosimilarity

• Nanomedicines and Nanosimilars: Looking for a New and Dynamic Regulatory “Astrolabe” Inspired System.  Demetzos C, Kavatzikidou P, Pippa N, Stratakis E. AAPS PharmSciTech.
• Fractal geometry as a new approach for proving nanosimilarity: A reflection note. C. Demetzos, N. Pippa. International Journal of Pharmaceutics, 2015.
• Fractal analysis as a complementary approach to predict the stability of drug delivery nano systems in aqueous and biological media: A regulatory proposal or a dream? C. Demetzos, N. Pippa.
  International Journal of Pharmaceutics, 2014.
• The significance of drug to lipid ratio to the development of optimized liposomal formulation. M. Chountoulesi, N. Naziris, N. Pippa, C. Demetzos. Journal of Liposome Research, 2017.
• The Thermal Analysis of Liposomal Formulations as an Element to Evaluate their Effectiveness as Drug and Vaccine Delivery Systems. N. Naziris, N. Pippa, S. Pispas, C. Demetzos. In: Liposomes: Historical, Clinical, and Molecular Perspectives, Ed: B.R. Pearson, Nova Science Publishers, 2017. Abstract Available.